Host-Host Interactions Enhanced the Structural Rigidity in a 6-Fold Interpenetrated Diamondoid Metal-Organic Framework Exhibiting C2H2/C2H4 Separation.

Multi-interpenetrated metal-organic frameworks (MOFs) have exhibited excellent performance in selective adsorption due to the variable post-interspersed flexibility, but the design and control remain challenging. Herein, two anthracene-based ligands, 4,4'-(anthracene-9,10-diyl)dibenzoic acid (H2L1) and 9,10-di(pyridin-4-yl)anthracene (L2), are used to construct a new three-dimensional 6-fold interpenetrated MOF [Zn(L1)(L2)]n (NBU-X1), which exhibits multiple C-H···π interactions that enhance the structural rigidity, thereby entangling with a C2H2/C2H4 separation performance. In this material, the incorporation of abundant anthracene rings within the framework not only partitions and restricts the pore window size to a quasi-double pore but also stabilizes it through host-host interactions. The structural stability upon heating or guest displacement/removal has been investigated by single-crystal X-ray diffraction and in situ variable-temperature powder X-ray diffraction, in contrast to the extreme flexibility of most multi-interpenetrated MOFs. The performance of purifying C2H4 from C2H2/C2H4 mixtures has been proved by dynamic breakthrough tests.

Polysubstitution Induced Centrosymmetric-to-Noncentrosymmetric Structural Transformation and Nonlinear-Optical Behavior: The Case of Na0.45Ag0.55Ga3Se5.

Obtaining compounds with large nonlinear-optical (NLO) coefficients and wide band gaps is challenging due to their competitive requirements for chemical bonds. Herein, the first member with mixed cations on the A site in the A-M3-Q5 or A-Ag-M6-Q10 (A = alkali metal; M = Ga, In; Q = S, Se, Te) family, viz. Na0.45Ag0.55Ga3Se5 (NAGSe), was obtained by a solid-state reaction. Its structure features [GaSe4] tetrahedra built three-dimensional {[Ga3Se5]-}∞ network, with Na and Na/Ag cations located at the octahedral cavities. Noncentrosymmetric (R32) NAGSe can also be transformed from centrosymmetric RbGa3S5 (P21/c) via multiple-site cosubstitution. NAGSe exhibits the highest NLO response (1.9 × AGS) in the A-Ag-M-Q family. Crystal structure analysis and theoretical calculations suggest that the NLO response is mainly contributed by the regularly arranged [GaSe4] units. This work enriches the exploration of the undeveloped A-M3-Q5 or A-Ag-M6-Q10 family as potential infrared NLO materials.

[GAO Wei-bin's clinical experience of electric eye acupuncture and stagnant-moving needling for ophthalmopathy].

Professor GAO Wei-bin's clinical experience of electric eye acupuncture and stagnant-moving needling for ophthalmopathy was introduced. The indications of electric eye acupuncture and stagnant-moving needling include external ophtalmoplegia and visual impairment. Professor GAO has proposed new acupoints at the ocular muscles attachment of eyeball, and put forward five experience points: Shangming point, Neiming point, Xiaming point, Waiming point and Tijian point. The points are selected according to different pathological changes of ocular muscles. In the treatment of ophthalmopathy, the tendons and vessels are often regulated at the same time. Neiming point, Shangming point, Xiaming point and Qiuhou point are the main points, with Fengchi (GB 20) and Gongxue (Extra) as the matching points. In addition, attention is paid to the application of stagnant-moving needling and electroacupuncture (continuous dense wave, frequency of 50 Hz).

NaGa3Se5: An Infrared Nonlinear Optical Material with Balanced Performance Contributed by Complex {[Ga3Se5]-}∞ Anionic Network.

Second-order nonlinear optical (NLO) materials are extensively applied in laser-related techniques. For developing IR NLO materials, chalcogenides are the main candidates. Here, NaGa3Se5 was explored as inspired by its unique anionic structure. It crystallizes with the orthorhombic chiral P212121 structure, featuring 12 types of GaSe4 tetrahedra built into a three-dimensional {[Ga3Se5]-}∞ anionic network, representing a new NLO-functional motif. NaGa3Se5 exhibits large and phase-matchable NLO response 1.37 × AgGaS2. It has the largest band gap among the noncentrosymmetric A-MIII-Se (A = alkali metal; M = Ga, In) compounds. The NLO properties' origin is explored via theoretical analysis. The success of NaGa3Se5 contributes a practical case for exploring new NLO materials.

New nonlinear optical-active AAgGa6S10 (A = K, Rb, Cs) featuring {[AgGa6S10]-}∞ framework and high laser damage threshold.

Obtaining new nonlinear-optical (NLO) materials with strong responses and wide band gaps is a hot topic in the laser field. Here, a series of sulfides AAgGa6S10 (A = K, Rb, Cs) were obtained by a facile solid-state reaction routine. They crystallize in the noncentrosymmetric space group Cc with a new structure-type. Their 3D structures are built by an unprecedented {[AgGa6S10]-}∞ anionic framework, which can be considered as the 1 : 1 intergrowth of the AgGaS2 and Ga2S3 structural slabs. They exhibit moderate responses ∼0.7/0.5/0.6 × AGS and the widest bandgaps among NLO chalcogenides containing independent Ag sites, suggesting that they may have high laser-induced damage thresholds, which is verified by the experimental 1.5/3/4 × AGS. This study not only opens a new system of NLO materials, but also provides a reliable design strategy for future NLO materials.

A novel promising infrared nonlinear optical selenide KAg3Ga8Se14 designed from benchmark AgGaQ2 (Q = S, Se).

Obtaining fresh nonlinear optical (NLO) materials is an attractive and challenging topic for the development of laser techniques. Using benchmark AgGaQ2 (Q = S, Se) as the template, new KAg3Ga8Se14 is obtained by a solid-state reaction. Its structure can be built by the intergrowth of 2 : 1 AgGaSe2 and Ga2Se3-like slabs if the K site is occupied by Ag. Powdery KAg3Ga8Se14 demonstrates moderate phase-matchable NLO responses, and a LDT of ca. 2 × AgGaS2. DFT calculations reveal that both AgSe4 and GaSe4 tetrahedral motifs contribute a lot to the NLO performance. This work reveals a new class of promising infrared NLO materials, and the design strategy may apply to other systems.

Prediction of Bone Metastasis in Breast Cancer Based on Minimal Driver Gene Set in Gene Dependency Network.

Bone is the most frequent organ for breast cancer metastasis, and thus it is essential to predict the bone metastasis of breast cancer. In our work, we constructed a gene dependency network based on the hypothesis that the relation between one gene and the risk of bone metastasis might be affected by another gene. Then, based on the structure controllability theory, we mined the driver gene set which can control the whole network in the gene dependency network, and the signature genes were selected from them. Survival analysis showed that the signature could distinguish the bone metastasis risks of cancer patients in the test data set and independent data set. Besides, we used the signature genes to construct a centroid classifier. The results showed that our method is effective and performed better than published methods.